About DNA damage-inducible transcript 4 protein
DNA damage-inducible transcript 4 protein (DDIT4) is a protein
from Homo sapiens identified by UniProt accession
Q9NX09, 232 residues long.
MolForge cross-references it against 0 known binders and
272 disease associations.
Target properties
| Protein name | DNA damage-inducible transcript 4 protein |
|---|
| UniProt accession | Q9NX09 |
|---|
| Gene | DDIT4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 232 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (272)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- cystatin C measurement · score 0.28
- lung adenocarcinoma · score 0.21
- head and neck squamous cell carcinoma · score 0.19
- squamous cell lung carcinoma · score 0.19
- endometrial cancer · score 0.18
- age at menarche · score 0.18
- hair color · score 0.18
- urinary bladder cancer · score 0.12
- neoplasm · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NX09-F1 | alphafold | PREDICTED | 71.29 | — |
Amino-acid sequence (232 residues)
MPSLWDRFSS SSTSSSPSSL PRTPTPDRPP RSAWGSATRE EGFDRSTSLE SSDCESLDSS NSGFGPEEDT AYLDGVSLPD FELLSDPEDE HLCANLMQLL QESLAQARLG SRRPARLLMP SQLVSQVGKE LLRLAYSEPC GLRGALLDVC VEQGKSCHSV GQLALDPSLV PTFQLTLVLR LDSRLWPKIQ GLFSSANSPF LPGFSQSLTL STGFRVIKKK LYSSEQLLIE EC
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