About Podocalyxin-like protein 2
Podocalyxin-like protein 2 (PODXL2) is a protein
from Homo sapiens identified by UniProt accession
Q9NZ53, 605 residues long.
MolForge cross-references it against 0 known binders and
60 disease associations.
Target properties
| Protein name | Podocalyxin-like protein 2 |
|---|
| UniProt accession | Q9NZ53 |
|---|
| Gene | PODXL2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 605 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (60)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.27
- Abnormality of refraction · score 0.25
- triglyceride measurement · score 0.25
- protein measurement · score 0.24
- BMI-adjusted waist-hip ratio · score 0.19
- waist-hip ratio · score 0.19
- refractive error · score 0.18
- risk-taking behaviour · score 0.16
- FEV/FVC ratio · score 0.15
- risky sexual behaviour measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NZ53-F1 | alphafold | PREDICTED | 54.43 | — |
Amino-acid sequence (605 residues)
MGRLLRAARL PPLLSPLLLL LVGGAFLGAC VAGSDEPGPE GLTSTSLLDL LLPTGLEPLD SEEPSETMGL GAGLGAPGSG FPSEENEESR ILQPPQYFWE EEEELNDSSL DLGPTADYVF PDLTEKAGSI EDTSQAQELP NLPSPLPKMN LVEPPWHMPP REEEEEEEEE EEREKEEVEK QEEEEEEELL PVNGSQEEAK PQVRDFSLTS SSQTPGATKS RHEDSGDQAS SGVEVESSMG PSLLLPSVTP TTVTPGDQDS TSQEAEATVL PAAGLGVEFE APQEASEEAT AGAAGLSGQH EEVPALPSFP QTTAPSGAEH PDEDPLGSRT SASSPLAPGD MELTPSSATL GQEDLNQQLL EGQAAEAQSR IPWDSTQVIC KDWSNLAGKN YIILNMTENI DCEVFRQHRG PQLLALVEEV LPRHGSGHHG AWHISLSKPS EKEQHLLMTL VGEQGVVPTQ DVLSMLGDIR RSLEEIGIQN YSTTSSCQAR ASQVRSDYGT LFVVLVVIGA ICIIIIALGL LYNCWQRRLP KLKHVSHGEE LRFVENGCHD NPTLDVASDS QSEMQEKHPS LNGGGALNGP GSWGALMGGK RDPEDSDVFE EDTHL
Explore Podocalyxin-like protein 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets