Triggering receptor expressed on myeloid cells 2…

About Triggering receptor expressed on myeloid cells 2

Triggering receptor expressed on myeloid cells 2 (TREM2) is a protein from Homo sapiens identified by UniProt accession Q9NZC2, 230 residues long. MolForge cross-references it against 0 known binders and 410 disease associations.

Target properties

Protein name	Triggering receptor expressed on myeloid cells 2
UniProt accession	Q9NZC2
Gene	TREM2
Organism	Homo sapiens
Length	230 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (410)

Diseases linked to this target (Open Targets).

Nasu-Hakola disease · score 0.80
frontotemporal dementia · score 0.40
genetic disorder · score 0.40
polycystic lipomembranous osteodysplasia with sclerosing leukoencephaly · score 0.38
Dystonia · score 0.37
C-reactive protein measurement · score 0.35
neoplasm · score 0.12
lung adenocarcinoma · score 0.11
hepatocellular carcinoma · score 0.11
cancer · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NZC2-F1	alphafold	PREDICTED	76.77	—

Amino-acid sequence (230 residues)

MEPLRLLILL FVTELSGAHN TTVFQGVAGQ SLQVSCPYDS MKHWGRRKAW CRQLGEKGPC QRVVSTHNLW LLSFLRRWNG STAITDDTLG GTLTITLRNL QPHDAGLYQC QSLHGSEADT LRKVLVEVLA DPLDHRDAGD LWFPGESESF EDAHVEHSIS RSLLEGEIPF PPTSILLLLA CIFLIKILAA SALWAAAWHG QKPGTHPPSE LDCGHDPGYQ LQTLPGLRDT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Triggering receptor expressed on myeloid cells 2 (TREM2)