ETS homologous factor (EHF)

About ETS homologous factor

ETS homologous factor (EHF) is a protein from Homo sapiens identified by UniProt accession Q9NZC4, 300 residues long. MolForge cross-references it against 0 known binders and 160 disease associations.

Target properties

Protein name	ETS homologous factor
UniProt accession	Q9NZC4
Gene	EHF
Organism	Homo sapiens
Length	300 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (160)

Diseases linked to this target (Open Targets).

serum gamma-glutamyl transferase measurement · score 0.50
hemoglobin measurement · score 0.38
serum alanine aminotransferase measurement · score 0.34
calcium measurement · score 0.33
blood protein measurement · score 0.26
CC16 measurement · score 0.23
chronic obstructive pulmonary disease · score 0.19
neurodegenerative disease · score 0.16
lung disease associated with cystic fibrosis · score 0.13
neoplasm · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NZC4-F1	alphafold	PREDICTED	67.91	—

Amino-acid sequence (300 residues)

MILEGGGVMN LNPGNNLLHQ PPAWTDSYST CNVSSGFFGG QWHEIHPQYW TKYQVWEWLQ HLLDTNQLDA NCIPFQEFDI NGEHLCSMSL QEFTRAAGTA GQLLYSNLQH LKWNGQCSSD LFQSTHNVIV KTEQTEPSIM NTWKDENYLY DTNYGSTVDL LDSKTFCRAQ ISMTTTSHLP VAESPDMKKE QDPPAKCHTK KHNPRGTHLW EFIRDILLNP DKNPGLIKWE DRSEGVFRFL KSEAVAQLWG KKKNNSSMTY EKLSRAMRYY YKREILERVD GRRLVYKFGK NARGWRENEN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards