About Killer cell lectin-like receptor subfamily F member 1
Killer cell lectin-like receptor subfamily F member 1 (KLRF1) is a protein
from Homo sapiens identified by UniProt accession
Q9NZS2, 231 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | Killer cell lectin-like receptor subfamily F member 1 |
|---|
| UniProt accession | Q9NZS2 |
|---|
| Gene | KLRF1 |
|---|
| Organism | Homo sapiens |
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| Length | 231 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (62)
Diseases linked to this target (Open Targets).
- Thyroid preparation use measurement · score 0.10
- lymphocyte count · score 0.06
- neoplasm · score 0.04
- Huntington disease · score 0.04
- myxedema · score 0.03
- inflammatory bowel disease · score 0.03
- myeloid white cell count · score 0.02
- Systemic lupus erythematosus · score 0.02
- urinary bladder carcinoma · score 0.02
- hepatocellular carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NZS2-F1 | alphafold | PREDICTED | 78.08 | — |
Amino-acid sequence (231 residues)
MQDEERYMTL NVQSKKRSSA QTSQLTFKDY SVTLHWYKIL LGISGTVNGI LTLTLISLIL LVSQGVLLKC QKGSCSNATQ YEDTGDLKVN NGTRRNISNK DLCASRSADQ TVLCQSEWLK YQGKCYWFSN EMKSWSDSYV YCLERKSHLL IIHDQLEMAF IQKNLRQLNY VWIGLNFTSL KMTWTWVDGS PIDSKIFFIK GPAKENSCAA IKESKIFSET CSSVFKWICQ Y
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