About ER membrane protein complex subunit 3
ER membrane protein complex subunit 3 (EMC3) is a protein
from Homo sapiens identified by UniProt accession
Q9P0I2, 261 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | ER membrane protein complex subunit 3 |
|---|
| UniProt accession | Q9P0I2 |
|---|
| Gene | EMC3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 261 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (44)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.56
- lysosomal storage disease · score 0.36
- body weight · score 0.33
- lean body mass · score 0.31
- fat body mass · score 0.17
- hip circumference · score 0.15
- body mass index · score 0.14
- base metabolic rate measurement · score 0.12
- body height · score 0.11
- blood protein measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P0I2-F1 | alphafold | PREDICTED | 77.66 | — |
Amino-acid sequence (261 residues)
MAGPELLLDS NIRLWVVLPI VIITFFVGMI RHYVSILLQS DKKLTQEQVS DSQVLIRSRV LRENGKYIPK QSFLTRKYYF NNPEDGFFKK TKRKVVPPSP MTDPTMLTDM MKGNVTNVLP MILIGGWINM TFSGFVTTKV PFPLTLRFKP MLQQGIELLT LDASWVSSAS WYFLNVFGLR SIYSLILGQD NAADQSRMMQ EQMTGAAMAM PADTNKAFKT EWEALELTDH QWALDDVEEE LMAKDLHFEG MFKKELQTSI F
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