About Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 (GCNT4) is a protein
from Homo sapiens identified by UniProt accession
Q9P109, 453 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 |
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| UniProt accession | Q9P109 |
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| Gene | GCNT4 |
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| Organism | Homo sapiens |
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| Length | 453 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (36)
Diseases linked to this target (Open Targets).
- C-reactive protein measurement · score 0.34
- aspartate aminotransferase measurement · score 0.33
- neurofibrillary tangles measurement · score 0.29
- body mass index · score 0.28
- low density lipoprotein cholesterol measurement · score 0.28
- total cholesterol measurement · score 0.27
- aspartate aminotransferase to alanine aminotransferase ratio · score 0.26
- neurodegenerative disease · score 0.19
- glioblastoma multiforme · score 0.13
- sitting height measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P109-F1 | alphafold | PREDICTED | 91.69 | — |
Amino-acid sequence (453 residues)
MKIFKCYFKH TLQQKVFILF LTLWLLSLLK LLNVRRLFPQ KDIYLVEYSL STSPFVRNRY THVKDEVRYE VNCSGIYEQE PLEIGKSLEI RRRDIIDLED DDVVAMTSDC DIYQTLRGYA QKLVSKEEKS FPIAYSLVVH KDAIMVERLI HAIYNQHNIY CIHYDRKAPD TFKVAMNNLA KCFSNIFIAS KLEAVEYAHI SRLQADLNCL SDLLKSSIQW KYVINLCGQD FPLKSNFELV SELKKLNGAN MLETVKPPNS KLERFTYHHE LRRVPYEYVK LPIRTNISKE APPHNIQIFV GSAYFVLSQA FVKYIFNNSI VQDFFAWSKD TYSPDEHFWA TLIRVPGIPG EISRSAQDVS DLQSKTRLVK WNYYEGFFYP SCTGSHLRSV CIYGAAELRW LIKDGHWFAN KFDSKVDPIL IKCLAEKLEE QQRDWITLPS EKLFMDRNLT TTS
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