About Kelch-like protein 9
Kelch-like protein 9 (KLHL9) is a protein
from Homo sapiens identified by UniProt accession
Q9P2J3, 617 residues long.
MolForge cross-references it against 0 known binders and
40 disease associations.
Target properties
| Protein name | Kelch-like protein 9 |
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| UniProt accession | Q9P2J3 |
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| Gene | KLHL9 |
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| Organism | Homo sapiens |
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| Length | 617 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (40)
Diseases linked to this target (Open Targets).
- KLHL9-related early-onset distal myopathy · score 0.37
- clear cell renal carcinoma · score 0.18
- genetic disorder · score 0.12
- Familial exudative vitreoretinopathy · score 0.05
- pyknoachondrogenesis · score 0.04
- Familial drusen · score 0.04
- melorheostosis · score 0.04
- drug use measurement · score 0.04
- X-linked retinoschisis · score 0.03
- Liberfarb syndrome · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9P2J3-F1 | alphafold | PREDICTED | 91.59 | — |
Amino-acid sequence (617 residues)
MKVSLGNGEM GVSAHLQPCK AGTTRFFTSN THSSVVLQGF DQLRIEGLLC DVTLVPGDGD EIFPVHRAMM ASASDYFKAM FTGGMKEQDL MCIKLHGVNK VGLKKIIDFI YTAKLSLNMD NLQDTLEAAS FLQILPVLDF CKVFLISGVS LDNCVEVGRI ANTYNLIEVD KYVNNFILKN FPALLSTGEF LKLPFERLAF VLSSNSLKHC TELELFKAAC RWLRLEDPRM DYAAKLMKNI RFPLMTPQDL INYVQTVDFM RTDNTCVNLL LEASNYQMMP YMQPVMQSDR TAIRSDSTHL VTLGGVLRQQ LVVSKELRMY DERAQEWRSL APMDAPRYQH GIAVIGNFLY VVGGQSNYDT KGKTAVDTVF RFDPRYNKWM QVASLNEKRT FFHLSALKGH LYAVGGRSAA GELATVECYN PRMNEWSYVA KMSEPHYGHA GTVYGGLMYI SGGITHDTFQ NELMCFDPDT DKWMQKAPMT TVRGLHCMCT VGDKLYVIGG NHFRGTSDYD DVLSCEYYSP TLDQWTPIAA MLRGQSDVGV AVFENKIYVV GGYSWNNRCM VEIVQKYDPE KDEWHKVFDL PESLGGIRAC TLTVFPPEEN PGSPSRESPL SAPSDHS
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