Kelch-like protein 42 (KLHL42)

About Kelch-like protein 42

Kelch-like protein 42 (KLHL42) is a protein from Homo sapiens identified by UniProt accession Q9P2K6, 505 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

Target properties

Protein name	Kelch-like protein 42
UniProt accession	Q9P2K6
Gene	KLHL42
Organism	Homo sapiens
Length	505 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.45
diabetes mellitus · score 0.42
pulse pressure measurement · score 0.38
gut microbiome measurement · score 0.36
osteoarthritis, hip · score 0.36
glucose measurement · score 0.35
Drugs used in diabetes use measurement · score 0.35
vital capacity · score 0.33
osteoarthritis · score 0.32
PHF-tau measurement · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9P2K6-F1	alphafold	PREDICTED	85.42	—

Amino-acid sequence (505 residues)

MSAEEMVQIR LEDRCYPVSK RKLIEQSDYF RALYRSGMRE ALSQEAGGPE VQQLRGLSAP GLRLVLDFIN AGGAREGWLL GPRGEKGGGV DEDEEMDEVS LLSELVEAAS FLQVTSLLQL LLSQVRLNNC LEMYRLAQVY GLPDLQEACL RFMVVHFHEV LCKPQFHLLG SPPQAPGDVS LKQRLREARM TGTPVLVALG DFLGGPLAPH PYQGEPPSML RYEEMTERWF PLANNLPPDL VNVRGYGSAI LDNYLFIVGG YRITSQEISA AHSYNPSTNE WLQVASMNQK RSNFKLVAVN SKLYAIGGQA VSNVECYNPE QDAWNFVAPL PNPLAEFSAC ECKGKIYVIG GYTTRDRNMN ILQYCPSSDM WTLFETCDVH IRKQQMVSVE ETIYIVGGCL HELGPNRRSS QSEDMLTVQS YNTVTRQWLY LKENTSKSGL NLTCALHNDG IYIMSRDVTL STSLEHRVFL KYNIFSDSWE AFRRFPAFGH NLLVSSLYLP NKAET

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards