Methyl-CpG-binding domain protein 2 (MBD2)

About Methyl-CpG-binding domain protein 2

Methyl-CpG-binding domain protein 2 (MBD2) is a protein from Homo sapiens identified by UniProt accession Q9UBB5, 411 residues long. MolForge cross-references it against 0 known binders and 299 disease associations.

Target properties

Protein name	Methyl-CpG-binding domain protein 2
UniProt accession	Q9UBB5
Gene	MBD2
Organism	Homo sapiens
Length	411 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (299)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.40
mean corpuscular volume · score 0.38
mean corpuscular hemoglobin concentration · score 0.36
mean corpuscular hemoglobin · score 0.36
leukocyte count · score 0.35
neutrophil count · score 0.34
mean reticulocyte volume · score 0.32
neuroticism measurement · score 0.29
myeloid white cell count · score 0.28
multiple sclerosis · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBB5-F1	alphafold	PREDICTED	67.02	—

Amino-acid sequence (411 residues)

MRAHPGGGRC CPEQEEGESA AGGSGAGGDS AIEQGGQGSA LAPSPVSGVR REGARGGGRG RGRWKQAGRG GGVCGRGRGR GRGRGRGRGR GRGRGRPPSG GSGLGGDGGG CGGGGSGGGG APRREPVPFP SGSAGPGPRG PRATESGKRM DCPALPPGWK KEEVIRKSGL SAGKSDVYYF SPSGKKFRSK PQLARYLGNT VDLSSFDFRT GKMMPSKLQK NKQRLRNDPL NQNKGKPDLN TTLPIRQTAS IFKQPVTKVT NHPSNKVKSD PQRMNEQPRQ LFWEKRLQGL SASDVTEQII KTMELPKGLQ GVGPGSNDET LLSAVASALH TSSAPITGQV SAAVEKNPAV WLNTSQPLCK AFIVTDEDIR KQEERVQQVR KKLEEALMAD ILSRAADTEE MDIEMDSGDE A

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards