About Serine/threonine-protein kinase NLK
Serine/threonine-protein kinase NLK (NLK) is a protein
from Homo sapiens identified by UniProt accession
Q9UBE8, 527 residues long.
MolForge cross-references it against 0 known binders and
145 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase NLK |
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| UniProt accession | Q9UBE8 |
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| Gene | NLK |
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| Organism | Homo sapiens |
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| Length | 527 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (145)
Diseases linked to this target (Open Targets).
- body mass index · score 0.25
- endometrial cancer · score 0.23
- neurodegenerative disease · score 0.22
- adolescent idiopathic scoliosis · score 0.11
- non-small cell lung carcinoma · score 0.08
- neoplasm · score 0.08
- glioblastoma multiforme · score 0.08
- Diamond-Blackfan anemia · score 0.08
- small cell lung carcinoma · score 0.07
- breast cancer · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBE8-F1 | alphafold | PREDICTED | 75.32 | — |
Amino-acid sequence (527 residues)
MSLCGARANA KMMAAYNGGT SAAAAGHHHH HHHHLPHLPP PHLHHHHHPQ HHLHPGSAAA VHPVQQHTSS AAAAAAAAAA AAAMLNPGQQ QPYFPSPAPG QAPGPAAAAP AQVQAAAAAT VKAHHHQHSH HPQQQLDIEP DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK RVFRELKMLC FFKHDNVLSA LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH VKVFLYQILR GLKYLHSAGI LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE VVTQYYRAPE ILMGSRHYSN AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP SLEAMRTACE GAKAHILRGP HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD ALAHPYLDEG RLRYHTCMCK CCFSTSTGRV YTSDFEPVTN PKFDDTFEKN LSSVRQVKEI IHQFILEQQK GNRVPLCINP QSAAFKSFIS STVAQPSEMP PSPLVWE
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