About Methionine synthase reductase
Methionine synthase reductase (MTRR) is a protein
from Homo sapiens identified by UniProt accession
Q9UBK8, 698 residues long.
MolForge cross-references it against 0 known binders and
154 disease associations.
Target properties
| Protein name | Methionine synthase reductase |
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| UniProt accession | Q9UBK8 |
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| Gene | MTRR |
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| Organism | Homo sapiens |
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| Length | 698 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (154)
Diseases linked to this target (Open Targets).
- methylcobalamin deficiency type cblE · score 0.82
- homocystinuria without methylmalonic aciduria · score 0.57
- isolated spina bifida · score 0.55
- genetic disorder · score 0.49
- methylmalonic aciduria and homocystinuria type cblG · score 0.46
- neurodegenerative disease · score 0.37
- methylmalonic aciduria and homocystinuria type cblE · score 0.37
- self reported educational attainment · score 0.35
- mean corpuscular volume · score 0.32
- mean corpuscular hemoglobin · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBK8-F1 | alphafold | PREDICTED | 85.32 | — |
Amino-acid sequence (698 residues)
MRRFLLLYAT QQGQAKAIAE EICEQAVVHG FSADLHCISE SDKYDLKTET APLVVVVSTT GTGDPPDTAR KFVKEIQNQT LPVDFFAHLR YGLLGLGDSE YTYFCNGGKI IDKRLQELGA RHFYDTGHAD DCVGLELVVE PWIAGLWPAL RKHFRSSRGQ EEISGALPVA SPASSRTDLV KSELLHIESQ VELLRFDDSG RKDSEVLKQN AVNSNQSNVV IEDFESSLTR SVPPLSQASL NIPGLPPEYL QVHLQESLGQ EESQVSVTSA DPVFQVPISK AVQLTTNDAI KTTLLVELDI SNTDFSYQPG DAFSVICPNS DSEVQSLLQR LQLEDKREHC VLLKIKADTK KKGATLPQHI PAGCSLQFIF TWCLEIRAIP KKAFLRALVD YTSDSAEKRR LQELCSKQGA ADYSRFVRDA CACLLDLLLA FPSCQPPLSL LLEHLPKLQP RPYSCASSSL FHPGKLHFVF NIVEFLSTAT TEVLRKGVCT GWLALLVASV LQPNIHASHE DSGKALAPKI SISPRTTNSF HLPDDPSIPI IMVGPGTGIA PFIGFLQHRE KLQEQHPDGN FGAMWLFFGC RHKDRDYLFR KELRHFLKHG ILTHLKVSFS RDAPVGEEEA PAKYVQDNIQ LHGQQVARIL LQENGHIYVC GDAKNMAKDV HDALVQIISK EVGVEKLEAM KTLATLKEEK RYLQDIWS
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