About Set1/Ash2 histone methyltransferase complex subunit ASH2
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L) is a protein
from Homo sapiens identified by UniProt accession
Q9UBL3, 628 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | Set1/Ash2 histone methyltransferase complex subunit ASH2 |
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| UniProt accession | Q9UBL3 |
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| Gene | ASH2L |
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| Organism | Homo sapiens |
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| Length | 628 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (64)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- Intellectual disability · score 0.27
- Global developmental delay · score 0.27
- endometrial cancer · score 0.26
- breast adenocarcinoma · score 0.26
- age at menopause · score 0.20
- congenital lipoid adrenal hyperplasia due to STAR deficency · score 0.19
- head and neck squamous cell carcinoma · score 0.17
- congenital adrenal hyperplasia · score 0.16
- clear cell renal carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBL3-F1 | alphafold | PREDICTED | 75.24 | — |
Amino-acid sequence (628 residues)
MAAAGAGPGQ EAGAGPGPGA VANATGAEEG EMKPVAAGAA APPGEGISAA PTVEPSSGEA EGGEANLVDV SGGLETESSN GKDTLEGAGD TSEVMDTQAG SVDEENGRQL GEVELQCGIC TKWFTADTFG IDTSSCLPFM TNYSFHCNVC HHSGNTYFLR KQANLKEMCL SALANLTWQS RTQDEHPKTM FSKDKDIIPF IDKYWECMTT RQRPGKMTWP NNIVKTMSKE RDVFLVKEHP DPGSKDPEED YPKFGLLDQD LSNIGPAYDN QKQSSAVSTS GNLNGGIAAG SSGKGRGAKR KQQDGGTTGT TKKARSDPLF SAQRLPPHGY PLEHPFNKDG YRYILAEPDP HAPDPEKLEL DCWAGKPIPG DLYRACLYER VLLALHDRAP QLKISDDRLT VVGEKGYSMV RASHGVRKGA WYFEITVDEM PPDTAARLGW SQPLGNLQAP LGYDKFSYSW RSKKGTKFHQ SIGKHYSSGY GQGDVLGFYI NLPEDTETAK SLPDTYKDKA LIKFKSYLYF EEKDFVDKAE KSLKQTPHSE IIFYKNGVNQ GVAYKDIFEG VYFPAISLYK SCTVSINFGP CFKYPPKDLT YRPMSDMGWG AVVEHTLADV LYHVETEVDG RRSPPWEP
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