About Spastin
Spastin (SPAST) is a protein
from Homo sapiens identified by UniProt accession
Q9UBP0, 616 residues long.
MolForge cross-references it against 0 known binders and
289 disease associations.
Target properties
| Protein name | Spastin |
|---|
| UniProt accession | Q9UBP0 |
|---|
| Gene | SPAST |
|---|
| Organism | Homo sapiens |
|---|
| Length | 616 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (289)
Diseases linked to this target (Open Targets).
- Autosomal dominant spastic paraplegia type 4 · score 0.87
- hereditary spastic paraplegia 4 · score 0.86
- hereditary spastic paraplegia · score 0.71
- Spastic paraplegia · score 0.57
- genetic disorder · score 0.52
- Rare hereditary ataxia · score 0.51
- Tip-toe gait · score 0.43
- cerebral palsy · score 0.42
- Spastic paraparesis · score 0.41
- Autosomal recessive spastic ataxia of Charlevoix-Saguenay · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBP0-F1 | alphafold | PREDICTED | 75.99 | — |
Amino-acid sequence (616 residues)
MNSPGGRGKK KGSGGASNPV PPRPPPPCLA PAPPAAGPAP PPESPHKRNL YYFSYPLFVG FALLRLVAFH LGLLFVWLCQ RFSRALMAAK RSSGAAPAPA SASAPAPVPG GEAERVRVFH KQAFEYISIA LRIDEDEKAG QKEQAVEWYK KGIEELEKGI AVIVTGQGEQ CERARRLQAK MMTNLVMAKD RLQLLEKMQP VLPFSKSQTD VYNDSTNLAC RNGHLQSESG AVPKRKDPLT HTSNSLPRSK TVMKTGSAGL SGHHRAPSYS GLSMVSGVKQ GSGPAPTTHK GTPKTNRTNK PSTPTTATRK KKDLKNFRNV DSNLANLIMN EIVDNGTAVK FDDIAGQDLA KQALQEIVIL PSLRPELFTG LRAPARGLLL FGPPGNGKTM LAKAVAAESN ATFFNISAAS LTSKYVGEGE KLVRALFAVA RELQPSIIFI DEVDSLLCER REGEHDASRR LKTEFLIEFD GVQSAGDDRV LVMGATNRPQ ELDEAVLRRF IKRVYVSLPN EETRLLLLKN LLCKQGSPLT QKELAQLARM TDGYSGSDLT ALAKDAALGP IRELKPEQVK NMSASEMRNI RLSDFTESLK KIKRSVSPQT LEAYIRWNKD FGDTTV
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