Cathepsin F (CTSF)

About Cathepsin F

Cathepsin F (CTSF) is a protein from Homo sapiens identified by UniProt accession Q9UBX1, 484 residues long. MolForge cross-references it against 0 known binders and 152 disease associations.

Target properties

Protein name	Cathepsin F
UniProt accession	Q9UBX1
Gene	CTSF
Organism	Homo sapiens
Length	484 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (152)

Diseases linked to this target (Open Targets).

neuronal ceroid lipofuscinosis 13 · score 0.76
CLN13 disease · score 0.72
neuronal ceroid lipofuscinosis · score 0.47
genetic disorder · score 0.47
adult neuronal ceroid lipofuscinosis · score 0.37
Neurodevelopmental disorder · score 0.33
neurodegenerative disease · score 0.16
blood protein measurement · score 0.16
chronotype measurement · score 0.12
bipolar disorder · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBX1-F1	alphafold	PREDICTED	82.12	—

Amino-acid sequence (484 residues)

MAPWLQLLSL LGLLPGAVAA PAQPRAASFQ AWGPPSPELL APTRFALEMF NRGRAAGTRA VLGLVRGRVR RAGQGSLYSL EATLEEPPCN DPMVCRLPVS KKTLLCSFQV LDELGRHVLL RKDCGPVDTK VPGAGEPKSA FTQGSAMISS LSQNHPDNRN ETFSSVISLL NEDPLSQDLP VKMASIFKNF VITYNRTYES KEEARWRLSV FVNNMVRAQK IQALDRGTAQ YGVTKFSDLT EEEFRTIYLN TLLRKEPGNK MKQAKSVGDL APPEWDWRSK GAVTKVKDQG MCGSCWAFSV TGNVEGQWFL NQGTLLSLSE QELLDCDKMD KACMGGLPSN AYSAIKNLGG LETEDDYSYQ GHMQSCNFSA EKAKVYINDS VELSQNEQKL AAWLAKRGPI SVAINAFGMQ FYRHGISRPL RPLCSPWLID HAVLLVGYGN RSDVPFWAIK NSWGTDWGEK GYYYLHRGSG ACGVNTMASS AVVD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards