About Poly [ADP-ribose] polymerase 2
Poly [ADP-ribose] polymerase 2 (PARP2) is a protein
from Homo sapiens identified by UniProt accession
Q9UGN5, 583 residues long.
MolForge cross-references it against 0 known binders and
213 disease associations.
Target properties
| Protein name | Poly [ADP-ribose] polymerase 2 |
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| UniProt accession | Q9UGN5 |
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| Gene | PARP2 |
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| Organism | Homo sapiens |
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| Length | 583 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (213)
Diseases linked to this target (Open Targets).
- ovarian cancer · score 0.63
- ovarian carcinoma · score 0.57
- ovarian neoplasm · score 0.56
- neoplasm · score 0.56
- Fallopian Tube Carcinoma · score 0.53
- peritoneal neoplasm · score 0.53
- breast neoplasm · score 0.52
- prostate cancer · score 0.51
- cancer · score 0.50
- breast carcinoma · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UGN5-F1 | alphafold | PREDICTED | 82.41 | — |
Amino-acid sequence (583 residues)
MAARRRRSTG GGRARALNES KRVNNGNTAP EDSSPAKKTR RCQRQESKKM PVAGGKANKD RTEDKQDGMP GRSWASKRVS ESVKALLLKG KAPVDPECTA KVGKAHVYCE GNDVYDVMLN QTNLQFNNNK YYLIQLLEDD AQRNFSVWMR WGRVGKMGQH SLVACSGNLN KAKEIFQKKF LDKTKNNWED REKFEKVPGK YDMLQMDYAT NTQDEEETKK EESLKSPLKP ESQLDLRVQE LIKLICNVQA MEEMMMEMKY NTKKAPLGKL TVAQIKAGYQ SLKKIEDCIR AGQHGRALME ACNEFYTRIP HDFGLRTPPL IRTQKELSEK IQLLEALGDI EIAIKLVKTE LQSPEHPLDQ HYRNLHCALR PLDHESYEFK VISQYLQSTH APTHSDYTMT LLDLFEVEKD GEKEAFREDL HNRMLLWHGS RMSNWVGILS HGLRIAPPEA PITGYMFGKG IYFADMSSKS ANYCFASRLK NTGLLLLSEV ALGQCNELLE ANPKAEGLLQ GKHSTKGLGK MAPSSAHFVT LNGSTVPLGP ASDTGILNPD GYTLNYNEYI VYNPNQVRMR YLLKVQFNFL QLW
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