Interleukin-36 alpha (IL36A)

About Interleukin-36 alpha

Interleukin-36 alpha (IL36A) is a protein from Homo sapiens identified by UniProt accession Q9UHA7, 158 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.

Target properties

Protein name	Interleukin-36 alpha
UniProt accession	Q9UHA7
Gene	IL36A
Organism	Homo sapiens
Length	158 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (133)

Diseases linked to this target (Open Targets).

psoriasis · score 0.09
hepatocellular carcinoma · score 0.08
psoriatic arthritis · score 0.08
basophil count · score 0.08
non-small cell lung carcinoma · score 0.07
Guillain-Barre syndrome · score 0.07
neoplasm · score 0.06
Bloom syndrome · score 0.06
inflammatory bowel disease · score 0.05
esophageal squamous cell carcinoma · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UHA7-F1	alphafold	PREDICTED	92.79	—

Amino-acid sequence (158 residues)

MEKALKIDTP QQGSIQDINH RVWVLQDQTL IAVPRKDRMS PVTIALISCR HVETLEKDRG NPIYLGLNGL NLCLMCAKVG DQPTLQLKEK DIMDLYNQPE PVKSFLFYHS QSGRNSTFES VAFPGWFIAV SSEGGCPLIL TQELGKANTT DFGLTMLF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards