About Signal recognition particle subunit SRP68
Signal recognition particle subunit SRP68 (SRP68) is a protein
from Homo sapiens identified by UniProt accession
Q9UHB9, 627 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Signal recognition particle subunit SRP68 |
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| UniProt accession | Q9UHB9 |
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| Gene | SRP68 |
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| Organism | Homo sapiens |
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| Length | 627 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- pancreatic adenocarcinoma · score 0.16
- alcohol consumption measurement · score 0.09
- lymphocyte count · score 0.03
- cancer · score 0.01
- neutropenia · score 0.01
- urothelial carcinoma · score 0.01
- Alzheimer disease · score 0.00
- Bartsocas-Papas syndrome 1 · score 0.00
- IGA glomerulonephritis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UHB9-F1 | alphafold | PREDICTED | 78.68 | — |
Amino-acid sequence (627 residues)
MAAEKQVPGG GGGGGSGGGG GSGGGGSGGG RGAGGEENKE NERPSAGSKA NKEFGDSLSL EILQIIKESQ QQHGLRHGDF QRYRGYCSRR QRRLRKTLNF KMGNRHKFTG KKVTEELLTD NRYLLLVLMD AERAWSYAMQ LKQEANTEPR KRFHLLSRLR KAVKHAEELE RLCESNRVDA KTKLEAQAYT AYLSGMLRFE HQEWKAAIEA FNKCKTIYEK LASAFTEEQA VLYNQRVEEI SPNIRYCAYN IGDQSAINEL MQMRLRSGGT EGLLAEKLEA LITQTRAKQA ATMSEVEWRG RTVPVKIDKV RIFLLGLADN EAAIVQAESE ETKERLFESM LSECRDAIQV VREELKPDQK QRDYILEGEP GKVSNLQYLH SYLTYIKLST AIKRNENMAK GLQRALLQQQ PEDDSKRSPR PQDLIRLYDI ILQNLVELLQ LPGLEEDKAF QKEIGLKTLV FKAYRCFFIA QSYVLVKKWS EALVLYDRVL KYANEVNSDA GAFKNSLKDL PDVQELITQV RSEKCSLQAA AILDANDAHQ TETSSSQVKD NKPLVERFET FCLDPSLVTK QANLVHFPPG FQPIPCKPLF FDLALNHVAF PPLEDKLEQK TKSGLTGYIK GIFGFRS
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