Adenine DNA glycosylase (MUTYH)

About Adenine DNA glycosylase

Adenine DNA glycosylase (MUTYH) is a protein from Homo sapiens identified by UniProt accession Q9UIF7, 546 residues long. MolForge cross-references it against 0 known binders and 360 disease associations.

Target properties

Protein name	Adenine DNA glycosylase
UniProt accession	Q9UIF7
Gene	MUTYH
Organism	Homo sapiens
Length	546 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (360)

Diseases linked to this target (Open Targets).

familial adenomatous polyposis 2 · score 0.85
Familial adenomatous polyposis · score 0.70
mutyh-associated polyposis · score 0.69
gastric cancer · score 0.68
colon carcinoma · score 0.61
colorectal cancer · score 0.59
hereditary neoplastic syndrome · score 0.58
Inherited cancer-predisposing syndrome · score 0.58
breast carcinoma · score 0.57
colorectal adenocarcinoma · score 0.55

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UIF7-F1	alphafold	PREDICTED	78.95	—

Amino-acid sequence (546 residues)

MTPLVSRLSR LWAIMRKPRA AVGSGHRKQA ASQEGRQKHA KNNSQAKPSA CDGMIAECPG APAGLARQPE EVVLQASVSS YHLFRDVAEV TAFRGSLLSW YDQEKRDLPW RRRAEDEMDL DRRAYAVWVS EVMLQQTQVA TVINYYTGWM QKWPTLQDLA SASLEEVNQL WAGLGYYSRG RRLQEGARKV VEELGGHMPR TAETLQQLLP GVGRYTAGAI ASIAFGQATG VVDGNVARVL CRVRAIGADP SSTLVSQQLW GLAQQLVDPA RPGDFNQAAM ELGATVCTPQ RPLCSQCPVE SLCRARQRVE QEQLLASGSL SGSPDVEECA PNTGQCHLCL PPSEPWDQTL GVVNFPRKAS RKPPREESSA TCVLEQPGAL GAQILLVQRP NSGLLAGLWE FPSVTWEPSE QLQRKALLQE LQRWAGPLPA THLRHLGEVV HTFSHIKLTY QVYGLALEGQ TPVTTVPPGA RWLTQEEFHT AAVSTAMKKV FRVYQGQQPG TCMGSKRSQV SSPCSRKKPR MGQQVLDNFF RSHISTDAHS LNSAAQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards