About Methyl-CpG-binding domain protein 1
Methyl-CpG-binding domain protein 1 (MBD1) is a protein
from Homo sapiens identified by UniProt accession
Q9UIS9, 605 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Target properties
| Protein name | Methyl-CpG-binding domain protein 1 |
|---|
| UniProt accession | Q9UIS9 |
|---|
| Gene | MBD1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 605 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (51)
Diseases linked to this target (Open Targets).
- 3-hydroxy-1-methylpropylmercapturic acid measurement · score 0.05
- Female infertility due to fertilization defect · score 0.05
- autosomal recessive spondylocostal dysostosis · score 0.05
- hemoglobin D disease · score 0.05
- female infertility due to oocyte meiotic arrest · score 0.04
- congenital amegakaryocytic thrombocytopenia · score 0.04
- premature ovarian failure 19 · score 0.04
- oocyte maturation defect 9 · score 0.04
- poisoning · score 0.04
- dominant beta-thalassemia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UIS9-F1 | alphafold | PREDICTED | 59.89 | — |
Amino-acid sequence (605 residues)
MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT LFDFKQGILC YPAPKAHPVA VASKKRKKPS RPAKTRKRQV GPQSGEVRKE APRDETKADT DTAPASFPAP GCCENCGISF SGDGTQRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTQEDCGHC PICLRPPRPG LRRQWKCVQR RCLRGKHARR KGGCDSKMAA RRRPGAQPLP PPPPSQSPEP TEPHPRALAP SPPAEFIYYC VDEDELQPYT NRRQNRKCGA CAACLRRMDC GRCDFCCDKP KFGGSNQKRQ KCRWRQCLQF AMKRLLPSVW SESEDGAGSP PPYRRRKRPS SARRHHLGPT LKPTLATRTA QPDHTQAPTK QEAGGGFVLP PPGTDLVFLR EGASSPVQVP GPVAASTEAL LQEAQCSGLS WVVALPQVKQ EKADTQDEWT PGTAVLTSPV LVPGCPSKAV DPGLPSVKQE PPDPEEDKEE NKDDSASKLA PEEEAGGAGT PVITEIFSLG GTRFRDTAVW LPRSKDLKKP GARKQ
Explore Methyl-CpG-binding domain protein 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets