2-hydroxyacyl-CoA lyase 1 (HACL1)

About 2-hydroxyacyl-CoA lyase 1

2-hydroxyacyl-CoA lyase 1 (HACL1) is a protein from Homo sapiens identified by UniProt accession Q9UJ83, 578 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	2-hydroxyacyl-CoA lyase 1
UniProt accession	Q9UJ83
Gene	HACL1
Organism	Homo sapiens
Length	578 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

biotinidase deficiency · score 0.19
protein measurement · score 0.19
coronary artery disease · score 0.07
Diarrhea · score 0.07
response to darapladib · score 0.07
mean platelet volume · score 0.06
electrocardiography · score 0.06
body mass index · score 0.05
body weight · score 0.05
blood protein measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UJ83-F1	alphafold	PREDICTED	95.25	—

Amino-acid sequence (578 residues)

MPDSNFAERS EEQVSGAKVI AQALKTQDVE YIFGIVGIPV TEIAIAAQQL GIKYIGMRNE QAACYAASAI GYLTSRPGVC LVVSGPGLIH ALGGMANANM NCWPLLVIGG SSERNQETMG AFQEFPQVEA CRLYTKFSAR PSSIEAIPFV IEKAVRSSIY GRPGACYVDI PADFVNLQVN VNSIKYMERC MSPPISMAET SAVCTAASVI RNAKQPLLII GKGAAYAHAE ESIKKLVEQY KLPFLPTPMG KGVVPDNHPY CVGAARSRAL QFADVIVLFG ARLNWILHFG LPPRYQPDVK FIQVDICAEE LGNNVKPAVT LLGNIHAVTK QLLEELDKTP WQYPPESKWW KTLREKMKSN EAASKELASK KSLPMNYYTV FYHVQEQLPR DCFVVSEGAN TMDIGRTVLQ NYLPRHRLDA GTFGTMGVGL GFAIAAAVVA KDRSPGQWII CVEGDSAFGF SGMEVETICR YNLPIILLVV NNNGIYQGFD TDTWKEMLKF QDATAVVPPM CLLPNSHYEQ VMTAFGGKGY FVQTPEELQK SLRQSLADTT KPSLINIMIE PQATRKAQDF HWLTRSNM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards