Guanine nucleotide-binding protein G(I)/G(S)/G(O)…

About Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 (GNG8) is a protein from Homo sapiens identified by UniProt accession Q9UK08, 70 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
UniProt accession	Q9UK08
Gene	GNG8
Organism	Homo sapiens
Length	70 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

endometrial cancer · score 0.28
head and neck squamous cell carcinoma · score 0.26
ulcerative colitis · score 0.05
Asperger syndrome · score 0.05
autism · score 0.05
15q11q13 microduplication syndrome · score 0.04
C-reactive protein measurement · score 0.04
autism spectrum disorder · score 0.04
Autism · score 0.04
P wave terminal force measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UK08-F1	alphafold	PREDICTED	90.29	—

Amino-acid sequence (70 residues)

MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV TPVPAAENPF RDKRLFCVLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 (GNG8)