U6 snRNA-associated Sm-like protein LSm7 (LSM7)

About U6 snRNA-associated Sm-like protein LSm7

U6 snRNA-associated Sm-like protein LSm7 (LSM7) is a protein from Homo sapiens identified by UniProt accession Q9UK45, 103 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	U6 snRNA-associated Sm-like protein LSm7
UniProt accession	Q9UK45
Gene	LSM7
Organism	Homo sapiens
Length	103 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
leukodystrophy · score 0.33
self reported educational attainment · score 0.20
neutrophil percentage of leukocytes · score 0.09
Parkinson disease · score 0.05
mathematical ability · score 0.04
cancer · score 0.02
neoplasm · score 0.01
ovarian carcinoma · score 0.01
Alzheimer disease · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UK45-F1	alphafold	PREDICTED	89.41	—

Amino-acid sequence (103 residues)

MADKEKKKKE SILDLSKYID KTIRVKFQGG REASGILKGF DPLLNLVLDG TIEYMRDPDD QYKLTEDTRQ LGLVVCRGTS VVLICPQDGM EAIPNPFIQQ QDA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards