About DnaJ homolog subfamily C member 12
DnaJ homolog subfamily C member 12 (DNAJC12) is a protein
from Homo sapiens identified by UniProt accession
Q9UKB3, 198 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | DnaJ homolog subfamily C member 12 |
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| UniProt accession | Q9UKB3 |
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| Gene | DNAJC12 |
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| Organism | Homo sapiens |
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| Length | 198 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (86)
Diseases linked to this target (Open Targets).
- hyperphenylalaninemia due to DNAJC12 deficiency · score 0.77
- mild hyperphenylalaninemia · score 0.54
- leukocyte count · score 0.42
- genetic disorder · score 0.41
- neutrophil count · score 0.39
- serum urea measurement · score 0.25
- cystatin C measurement · score 0.25
- systolic blood pressure · score 0.22
- mean platelet volume · score 0.13
- platelet count · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UKB3-F1 | alphafold | PREDICTED | 68.41 | — |
Amino-acid sequence (198 residues)
MDAILNYRSE DTEDYYTLLG CDELSSVEQI LAEFKVRALE CHPDKHPENP KAVETFQKLQ KAKEILTNEE SRARYDHWRR SQMSMPFQQW EALNDSVKTS MHWVVRGKKD LMLEESDKTH TTKMENEECN EQRERKKEEL ASTAEKTEQK EPKPLEKSVS PQNSDSSGFA DVNGWHLRFR WSKDAPSELL RKFRNYEI
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