Beta-citrylglutamate synthase B (RIMKLB)

About Beta-citrylglutamate synthase B

Beta-citrylglutamate synthase B (RIMKLB) is a protein from Homo sapiens identified by UniProt accession Q9ULI2, 386 residues long. MolForge cross-references it against 0 known binders and 142 disease associations.

Target properties

Protein name	Beta-citrylglutamate synthase B
UniProt accession	Q9ULI2
Gene	RIMKLB
Organism	Homo sapiens
Length	386 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (142)

Diseases linked to this target (Open Targets).

reticulocyte count · score 0.41
mean platelet volume · score 0.40
Calcium channel blocker use measurement · score 0.37
platelet count · score 0.36
reticulocyte measurement · score 0.36
hypertension · score 0.34
Immature Reticulocyte Fraction Measurement · score 0.34
lymphocyte count · score 0.33
diastolic blood pressure · score 0.32
neurodegenerative disease · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9ULI2-F1	alphafold	PREDICTED	80.64	—

Amino-acid sequence (386 residues)

MCSSVAAKLW FLTDRRIRED YPQKEILRAL KAKCCEEELD FRAVVMDEVV LTIEQGNLGL RINGELITAY PQVVVVRVPT PWVQSDSDIT VLRHLEKMGC RLMNRPQAIL NCVNKFWTFQ ELAGHGVPLP DTFSYGGHEN FAKMIDEAEV LEFPMVVKNT RGHRGKAVFL ARDKHHLADL SHLIRHEAPY LFQKYVKESH GRDVRVIVVG GRVVGTMLRC STDGRMQSNC SLGGVGMMCS LSEQGKQLAI QVSNILGMDV CGIDLLMKDD GSFCVCEANA NVGFIAFDKA CNLDVAGIIA DYAASLLPSG RLTRRMSLLS VVSTASETSE PELGPPASTA VDNMSASSSS VDSDPESTER ELLTKLPGGL FNMNQLLANE IKLLVD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards