Zinc finger protein PLAGL1 (PLAGL1)

About Zinc finger protein PLAGL1

Zinc finger protein PLAGL1 (PLAGL1) is a protein from Homo sapiens identified by UniProt accession Q9UM63, 463 residues long. MolForge cross-references it against 0 known binders and 167 disease associations.

Target properties

Protein name	Zinc finger protein PLAGL1
UniProt accession	Q9UM63
Gene	PLAGL1
Organism	Homo sapiens
Length	463 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (167)

Diseases linked to this target (Open Targets).

testosterone measurement · score 0.48
monocyte count · score 0.46
monocyte percentage of leukocytes · score 0.43
eosinophil count · score 0.42
lymphocyte percentage of leukocytes · score 0.37
neutrophil percentage of leukocytes · score 0.37
transient neonatal diabetes mellitus · score 0.37
neurodegenerative disease · score 0.35
resistin measurement · score 0.34
body mass index · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UM63-F1	alphafold	PREDICTED	56.59	—

Amino-acid sequence (463 residues)

MATFPCQLCG KTFLTLEKFT IHNYSHSRER PYKCVQPDCG KAFVSRYKLM RHMATHSPQK SHQCAHCEKT FNRKDHLKNH LQTHDPNKMA FGCEECGKKY NTMLGYKRHL ALHAASSGDL TCGVCALELG STEVLLDHLK AHAEEKPPSG TKEKKHQCDH CERCFYTRKD VRRHLVVHTG CKDFLCQFCA QRFGRKDHLT RHTKKTHSQE LMKESLQTGD LLSTFHTISP SFQLKAAALP PFPLGASAQN GLASSLPAEV HSLTLSPPEQ AAQPMQPLPE SLASLHPSVS PGSPPPPLPN HKYNTTSTSY SPLASLPLKA DTKGFCNISL FEDLPLQEPQ SPQKLNPGFD LAKGNAGKVN LPKELPADAV NLTIPASLDL SPLLGFWQLP PPATQNTFGN STLALGPGES LPHRLSCLGQ QQQEPPLAMG TVSLGQLPLP PIPHVFSAGT GSAILPHFHH AFR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards