T-box transcription factor TBX20 (TBX20)

About T-box transcription factor TBX20

T-box transcription factor TBX20 (TBX20) is a protein from Homo sapiens identified by UniProt accession Q9UMR3, 447 residues long. MolForge cross-references it against 0 known binders and 166 disease associations.

Target properties

Protein name	T-box transcription factor TBX20
UniProt accession	Q9UMR3
Gene	TBX20
Organism	Homo sapiens
Length	447 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (166)

Diseases linked to this target (Open Targets).

atrial heart septal defect · score 0.68
Abnormality of the cardiovascular system · score 0.49
QRS duration · score 0.43
birth weight · score 0.42
electrocardiography · score 0.40
aortic measurement · score 0.37
atrial septal defect, ostium secundum type · score 0.37
diet measurement · score 0.36
body height · score 0.34
congenital left-sided heart lesions · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UMR3-F1	alphafold	PREDICTED	66.55	—

Amino-acid sequence (447 residues)

MEFTASPKPQ LSSRANAFSI AALMSSGGSK EKEATENTIK PLEQFVEKSS CAQPLGELTS LDAHGEFGGG SGSSPSSSSL CTEPLIPTTP IIPSEEMAKI ACSLETKELW DKFHELGTEM IITKSGRRMF PTIRVSFSGV DPEAKYIVLM DIVPVDNKRY RYAYHRSSWL VAGKADPPLP ARLYVHPDSP FTGEQLLKQM VSFEKVKLTN NELDQHGHII LNSMHKYQPR VHIIKKKDHT ASLLNLKSEE FRTFIFPETV FTAVTAYQNQ LITKLKIDSN PFAKGFRDSS RLTDIERESV ESLIQKHSYA RSPIRTYGGE EDVLGDESQT TPNRGSAFTT SDNLSLSSWV SSSSSFPGFQ HPQSLTALGT STASIATPIP HPIQGSLPPY SRLGMPLTPS AIASSMQGSG PTFPSFHMPR YHHYFQQGPY AAIQGLRHSS AVMTPFV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards