About Protocadherin beta-8
Protocadherin beta-8 (PCDHB8) is a protein
from Homo sapiens identified by UniProt accession
Q9UN66, 801 residues long.
MolForge cross-references it against 0 known binders and
9 disease associations.
Target properties
| Protein name | Protocadherin beta-8 |
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| UniProt accession | Q9UN66 |
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| Gene | PCDHB8 |
|---|
| Organism | Homo sapiens |
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| Length | 801 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (9)
Diseases linked to this target (Open Targets).
- leukocyte count · score 0.13
- body height · score 0.12
- myeloid white cell count · score 0.05
- cancer · score 0.00
- neoplasm · score 0.00
- age-related macular degeneration · score 0.00
- calf circumference measurement · score 0.00
- Tetralogy of Fallot · score 0.00
- colorectal cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UN66-F1 | alphafold | PREDICTED | 80.95 | — |
Amino-acid sequence (801 residues)
MEASGKLICR QRQVLFSFLL LGLSLAGAAE PRSYSVVEET EGSSFVTNLA KDLGLEQREF SRRGVRVVSR GNKLHLQLNQ ETADLLLNEK LDREDLCGHT EPCVLRFQVL LESPFEFFQA ELQVIDINDH SPVFLDKQML VKVSESSPPG TAFPLKNAED LDIGQNNIEN YIISPNSYFR VLTRKRSDGR KYPELVLDKA LDREEEAELR LTLTALDGGS PPRSGTAQVY IEVVDVNDNA PEFEQPFYRV QISEDSPISF LVVKVSATDV DTGVNGEISY SLFQASDEIS KTFKVDFLTG EIRLKKQLDF EKFQSYEVNI EARDAGGFSG KCTVLIQVID VNDHAPEVTM SAFTSPIPEN APETVVALFS VSDLDSGENG KISCSIQEDL PFLLKSSVGN FYTLLTETPL DRESRAEYNV TITVTDLGTP RLTTHLNMTV LVSDVNDNAP AFTQTSYTLF VRENNSPALH IGSVSATDRD SGTNAQVTYS LLPPQDPHLP LASLVSINTD NGHLFALRSL DYEALQAFEF RVGASDRGSP ALSSEALVRV LVLDANDNSP FVLYPLQNGS APCTELVPRA AEPGYLVTKV VAVDGDSGQN AWLSYQLLKA TEPGLFGVWA HNGEVRTARL LSERDAAKQR LVVLVKDNGE PPCSATATLH VLLVDGFSQP YLPLPEAAPA QGQADSLTVY LVVALASVSS LFLFSVLLFV AVLLCRRSRA ASVGRCSVPE GPFPGHLVDV RGTGSLSQNY QYEVCLAGGS GTNEFQLLKP VLPNIQGHSF GPEMEQNSNF RNGFGFSLQL K
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