TFIIA-alpha and beta-like factor (GTF2A1L)

About TFIIA-alpha and beta-like factor

TFIIA-alpha and beta-like factor (GTF2A1L) is a protein from Homo sapiens identified by UniProt accession Q9UNN4, 478 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	TFIIA-alpha and beta-like factor
UniProt accession	Q9UNN4
Gene	GTF2A1L
Organism	Homo sapiens
Length	478 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

Leydig cell hypoplasia, type 1 · score 0.56
peripheral precocious puberty · score 0.54
Leydig cell hypoplasia · score 0.47
pseudohermaphroditism · score 0.33
testosterone measurement · score 0.31
body mass index · score 0.31
age at menopause · score 0.26
neurodegenerative disease · score 0.23
mean corpuscular hemoglobin · score 0.20
triglyceride measurement · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UNN4-F1	alphafold	PREDICTED	53.00	—

Amino-acid sequence (478 residues)

MACLNPVPKL YRSVIEDVIE GVRNLFAEEG IEEQVLKDLK QLWETKVLQS KATEDFFRNS IQSPLFTLQL PHSLHQTLQS STASLVIPAG RTLPSFTTAE LGTSNSSANF TFPGYPIHVP AGVTLQTVSG HLYKVNVPIM VTETSGRAGI LQHPIQQVFQ QLGQPSVIQT SVPQLNPWSL QATTEKSQRI ETVLQQPAIL PSGPVDRKHL ENATSDILVS PGNEHKIVPE ALLCHQESSH YISLPGVVFS PQVSQTNSNV ESVLSGSASM AQNLHDESLS TSPHGALHQH VTDIQLHILK NRMYGCDSVK QPRNIEEPSN IPVSEKDSNS QVDLSIRVTD DDIGEIIQVD GSGDTSSNEE IGSTRDADEN EFLGNIDGGD LKVPEEEADS ISNEDSATNS SDNEDPQVNI VEEDPLNSGD DVSEQDVPDL FDTDNVIVCQ YDKIHRSKNK WKFYLKDGVM CFGGRDYVFA KAIGDAEW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards