About Rab-like protein 2B
Rab-like protein 2B (RABL2B) is a protein
from Homo sapiens identified by UniProt accession
Q9UNT1, 228 residues long.
MolForge cross-references it against 0 known binders and
115 disease associations.
Target properties
| Protein name | Rab-like protein 2B |
|---|
| UniProt accession | Q9UNT1 |
|---|
| Gene | RABL2B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 228 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (115)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.09
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.09
- spermatogenic failure 63 · score 0.08
- spermatogenic failure 10 · score 0.08
- spermatogenic failure 11 · score 0.08
- spermatogenic failure 47 · score 0.08
- spermatogenic failure 40 · score 0.08
- spermatogenic failure 7 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UNT1-F1 | alphafold | PREDICTED | 79.52 | — |
Amino-acid sequence (228 residues)
MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ LSTYALTLYK HTATVDGRTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV FDVQRKVTYR NLSTWYTELR EFRPEIPCIV VANKIDDINV TQKSFNFAKK FSLPLYFVSA ADGTNVVKLF NDAIRLAVSY KQNSQDFMDE IFQELENFSL EQEEEDVPDQ EQSSSIETPS EEAASPHS
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