About RNA-binding protein Nova-2
RNA-binding protein Nova-2 (NOVA2) is a protein
from Homo sapiens identified by UniProt accession
Q9UNW9, 492 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | RNA-binding protein Nova-2 |
|---|
| UniProt accession | Q9UNW9 |
|---|
| Gene | NOVA2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 492 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (37)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with or without autistic features and/or structural brain abnormalities · score 0.66
- Neurodevelopmental disorder · score 0.37
- Intellectual disability, severe · score 0.34
- Intellectual disability · score 0.33
- genetic disorder · score 0.19
- chronotype measurement · score 0.14
- electrocardiography · score 0.12
- neuroticism measurement · score 0.08
- hematocrit · score 0.02
- Ataxia-telangiectasia · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UNW9-F1 | alphafold | PREDICTED | 63.54 | — |
Amino-acid sequence (492 residues)
MEPEAPDSRK RPLETPPEVV CTKRSNTGEE GEYFLKVLIP SYAAGSIIGK GGQTIVQLQK ETGATIKLSK SKDFYPGTTE RVCLVQGTAE ALNAVHSFIA EKVREIPQAM TKPEVVNILQ PQTTMNPDRA KQAKLIVPNS TAGLIIGKGG ATVKAVMEQS GAWVQLSQKP EGINLQERVV TVSGEPEQVH KAVSAIVQKV QEDPQSSSCL NISYANVAGP VANSNPTGSP YASPADVLPA AAAASAAAAS GLLGPAGLAG VGAFPAALPA FSGTDLLAIS TALNTLASYG YNTNSLGLGL NSAAASGVLA AVAAGANPAA AAAANLLASY AGEAGAGPAG GAAPPPPPPP GALGSFALAA AANGYLGAGA GGGAGGGGGP LVAAAAAAGA AGGFLTAEKL AAESAKELVE IAVPENLVGA ILGKGGKTLV EYQELTGARI QISKKGEFLP GTRNRRVTIT GSPAATQAAQ YLISQRVTYE QGVRASNPQK VG
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