About Cystine/glutamate transporter
Cystine/glutamate transporter (SLC7A11) is a protein
from Homo sapiens identified by UniProt accession
Q9UPY5, 501 residues long.
MolForge cross-references it against 0 known binders and
457 disease associations.
Target properties
| Protein name | Cystine/glutamate transporter |
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| UniProt accession | Q9UPY5 |
|---|
| Gene | SLC7A11 |
|---|
| Organism | Homo sapiens |
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| Length | 501 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (457)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.50
- neuroticism measurement · score 0.41
- eosinophil percentage of leukocytes · score 0.41
- body height · score 0.37
- wellbeing measurement · score 0.35
- mood instability measurement · score 0.27
- depressive symptom measurement · score 0.26
- serum metabolite measurement · score 0.25
- neurotic disorder · score 0.24
- smoking behaviour measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UPY5-F1 | alphafold | PREDICTED | 85.59 | — |
Amino-acid sequence (501 residues)
MVRKPVVSTI SKGGYLQGNV NGRLPSLGNK EPPGQEKVQL KRKVTLLRGV SIIIGTIIGA GIFISPKGVL QNTGSVGMSL TIWTVCGVLS LFGALSYAEL GTTIKKSGGH YTYILEVFGP LPAFVRVWVE LLIIRPAATA VISLAFGRYI LEPFFIQCEI PELAIKLITA VGITVVMVLN SMSVSWSARI QIFLTFCKLT AILIIIVPGV MQLIKGQTQN FKDAFSGRDS SITRLPLAFY YGMYAYAGWF YLNFVTEEVE NPEKTIPLAI CISMAIVTIG YVLTNVAYFT TINAEELLLS NAVAVTFSER LLGNFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH LPEILSMIHV RKHTPLPAVI VLHPLTMIML FSGDLDSLLN FLSFARWLFI GLAVAGLIYL RYKCPDMHRP FKVPLFIPAL FSFTCLFMVA LSLYSDPFST GIGFVITLTG VPAYYLFIIW DKKPRWFRIM SEKITRTLQI ILEVVPEEDK L
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