About TRAF3-interacting JNK-activating modulator
TRAF3-interacting JNK-activating modulator (TRAF3IP3) is a protein
from Homo sapiens identified by UniProt accession
Q9Y228, 551 residues long.
MolForge cross-references it against 0 known binders and
190 disease associations.
Target properties
| Protein name | TRAF3-interacting JNK-activating modulator |
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| UniProt accession | Q9Y228 |
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| Gene | TRAF3IP3 |
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| Organism | Homo sapiens |
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| Length | 551 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (190)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.37
- mean corpuscular hemoglobin · score 0.34
- mean reticulocyte volume · score 0.32
- erythrocyte count · score 0.31
- neutrophil count · score 0.30
- mean corpuscular hemoglobin concentration · score 0.30
- red blood cell density measurement · score 0.28
- systolic blood pressure · score 0.26
- IGF-1 measurement · score 0.26
- leukocyte count · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y228-F1 | alphafold | PREDICTED | 74.02 | — |
Amino-acid sequence (551 residues)
MISPDPRPSP GLARWAESYE AKCERRQEIR ESRRCRPNVT TCRQVGKTLR IQQREQLQRA RLQQFFRRRN LELEEKGKAQ HPQAREQGPS RRPGQVTVLK EPLSCARRIS SPREQVTGTS SEVFPAQHPP PSGICRDLSD HLSSQAGGLP PQDTPIKKPP KHHRGTQTKA EGPTIKNDAS QQTNYGVAVL DKEIIQLSDY LKEALQRELV LKQKMVILQD LLSTLIQASD SSWKGQLNED KLKGKLRSLE NQLYTCTQKY SPWGMKKVLL EMEDQKNSYE QKAKESLQKV LEEKMNAEQQ LQSTQRSLAL AEQKCEEWRS QYEALKEDWR TLGTQHRELE SQLHVLQSKL QGADSRDLQM NQALRFLENE HQQLQAKIEC LQGDRDLCSL DTQDLQDQLK RSEAEKLTLV TRVQQLQGLL QNQSLQLQEQ EKLLTKKDQA LPVWSPKSFP NEVEPEGTGK EKDWDLRDQL QKKTLQLQAK EKECRELHSE LDNLSDEYLS CLRKLQHCRE ELNQSQQLPP RRQCGRWLPV LMVVIAAALA VFLANKDNLM I
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