About E3 ubiquitin-protein ligase RNF6
E3 ubiquitin-protein ligase RNF6 (RNF6) is a protein
from Homo sapiens identified by UniProt accession
Q9Y252, 685 residues long.
MolForge cross-references it against 0 known binders and
77 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF6 |
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| UniProt accession | Q9Y252 |
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| Gene | RNF6 |
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| Organism | Homo sapiens |
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| Length | 685 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (77)
Diseases linked to this target (Open Targets).
- esophageal squamous cell carcinoma · score 0.55
- type 2 diabetes mellitus · score 0.48
- glucose measurement · score 0.40
- Drugs used in diabetes use measurement · score 0.38
- esophageal cancer · score 0.37
- HbA1c measurement · score 0.32
- sex hormone-binding globulin measurement · score 0.21
- colorectal adenocarcinoma · score 0.19
- pancreatic adenocarcinoma · score 0.18
- Miyoshi myopathy · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y252-F1 | alphafold | PREDICTED | 49.46 | — |
Amino-acid sequence (685 residues)
MNQSRSRSDG GSEETLPQDH NHHENERRWQ QERLHREEAY YQFINELNDE DYRLMRDHNL LGTPGEITSE ELQQRLDGVK EQLASQPDLR DGTNYRDSEV PRESSHEDSL LEWLNTFRRT GNATRSGQNG NQTWRAVSRT NPNNGEFRFS LEIHVNHENR GFEIHGEDYT DIPLSDSNRD HTANRQQRST SPVARRTRSQ TSVNFNGSSS NIPRTRLASR GQNPAEGSFS TLGRLRNGIG GAAGIPRANA SRTNFSSHTN QSGGSELRQR EGQRFGAAHV WENGARSNVT VRNTNQRLEP IRLRSTSNSR SRSPIQRQSG TVYHNSQRES RPVQQTTRRS VRRRGRTRVF LEQDRERERR GTAYTPFSNS RLVSRITVEE GEESSRSSTA VRRHPTITLD LQVRRIRPGE NRDRDSIANR TRSRVGLAEN TVTIESNSGG FRRTISRLER SGIRTYVSTI TVPLRRISEN ELVEPSSVAL RSILRQIMTG FGELSSLMEA DSESELQRNG QHLPDMHSEL SNLGTDNNRS QHREGSSQDR QAQGDSTEMH GENETTQPHT RNSDSRGGRQ LRNPNNLVET GTLPILRLAH FFLLNESDDD DRIRGLTKEQ IDNLSTRHYE HNSIDSELGK ICSVCISDYV TGNKLRQLPC MHEFHIHCID RWLSENCTCP ICRQPVLGSN IANNG
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