Choline/ethanolamine kinase (CHKB)

About Choline/ethanolamine kinase

Choline/ethanolamine kinase (CHKB) is a protein from Homo sapiens identified by UniProt accession Q9Y259, 395 residues long. MolForge cross-references it against 0 known binders and 264 disease associations.

Target properties

Protein name	Choline/ethanolamine kinase
UniProt accession	Q9Y259
Gene	CHKB
Organism	Homo sapiens
Length	395 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (264)

Diseases linked to this target (Open Targets).

megaconial type congenital muscular dystrophy · score 0.72
Congenital muscular dystrophy due to phosphatidylcholine biosynthesis defect · score 0.70
neurodegenerative disease · score 0.39
muscular dystrophy · score 0.28
genetic disorder · score 0.19
breast adenocarcinoma · score 0.18
neurofibrillary tangles measurement · score 0.13
Seizure · score 0.12
Severe global developmental delay · score 0.12
mean corpuscular volume · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y259-F1	alphafold	PREDICTED	85.10	—

Amino-acid sequence (395 residues)

MAAEATAVAG SGAVGGCLAK DGLQQSKCPD TTPKRRRASS LSRDAERRAY QWCREYLGGA WRRVQPEELR VYPVSGGLSN LLFRCSLPDH LPSVGEEPRE VLLRLYGAIL QGVDSLVLES VMFAILAERS LGPQLYGVFP EGRLEQYIPS RPLKTQELRE PVLSAAIATK MAQFHGMEMP FTKEPHWLFG TMERYLKQIQ DLPPTGLPEM NLLEMYSLKD EMGNLRKLLE STPSPVVFCH NDIQEGNILL LSEPENADSL MLVDFEYSSY NYRGFDIGNH FCEWVYDYTH EEWPFYKARP TDYPTQEQQL HFIRHYLAEA KKGETLSQEE QRKLEEDLLV EVSRYALASH FFWGLWSILQ ASMSTIEFGY LDYAQSRFQF YFQQKGQLTS VHSSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards