About Histone chaperone ASF1A
Histone chaperone ASF1A (ASF1A) is a protein
from Homo sapiens identified by UniProt accession
Q9Y294, 204 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Histone chaperone ASF1A |
|---|
| UniProt accession | Q9Y294 |
|---|
| Gene | ASF1A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 204 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (69)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.43
- self reported educational attainment · score 0.35
- erythrocyte count · score 0.34
- testosterone measurement · score 0.34
- FEV/FVC ratio · score 0.34
- platelet count · score 0.30
- mathematical ability · score 0.28
- dehydroepiandrosterone sulphate measurement · score 0.27
- breast adenocarcinoma · score 0.26
- neurodegenerative disease · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y294-F1 | alphafold | PREDICTED | 84.13 | — |
Amino-acid sequence (204 residues)
MAKVQVNNVV VLDNPSPFYN PFQFEITFEC IEDLSEDLEW KIIYVGSAES EEYDQVLDSV LVGPVPAGRH MFVFQADAPN PGLIPDADAV GVTVVLITCT YRGQEFIRVG YYVNNEYTET ELRENPPVKP DFSKLQRNIL ASNPRVTRFH INWEDNTEKL EDAESSNPNL QSLLSTDALP SASKGWSTSE NSLNVMLESH MDCM
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