About Little elongation complex subunit 1
Little elongation complex subunit 1 (ICE1) is a protein
from Homo sapiens identified by UniProt accession
Q9Y2F5, 2266 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Little elongation complex subunit 1 |
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| UniProt accession | Q9Y2F5 |
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| Gene | ICE1 |
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| Organism | Homo sapiens |
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| Length | 2266 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (26)
Diseases linked to this target (Open Targets).
- appendicular lean mass · score 0.33
- neurofibrillary tangles measurement · score 0.20
- lean body mass · score 0.19
- Hernia of the abdominal wall · score 0.16
- body weights and measures · score 0.15
- Inguinal hernia · score 0.13
- body height · score 0.13
- PHF-tau measurement · score 0.12
- disease free survival · score 0.12
- refractive error measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y2F5-F1 | alphafold | PREDICTED | 44.35 | — |
Amino-acid sequence (2266 residues)
MMPGETHSAA PGTAADLSRC QGCASLQQNL NEYVEALITL KQKIINTDNL LTEYQKKCDE LQFARRENSN LHHQVEEMLQ KISPLQKCQE ELGSLKAELE EKKSSLKLYQ DTHQEYARVK EECLKSDAQK KKLEAKVKKL QEAAVKQTQD FKQLRNEKKI LEKEFKKTQE RLDEFSKQKN EKELRHIGTQ ISSDSYGSID KRKVKLLLKE LWLCVNTTHR LPGEGSRCVP EKPAKAITSS RVPGEDGTLP PTQGSPLRTS NVQTCLTKLS MEIKEDFLCQ NVEKQSSSGT NCSSDHVFNE NGNLEVLVQS HRDGGSTEFV DHDHFFDEDL QAAIDFFKLP PPLLSPVPSP PPMSSPHPGS LPSSFAPETY FGEYTDSSDN DSVQLRNSAE CVSEDDTTES QNYFGSLRKN KGSGTWEEKP KSHEAIQALN TWEVNKVTTS GLETFTATLR ESSATHSLVG EKHWTTASRS MSDRKRDILH ETKTQMEVRE MDKSVQTEKT IHKLTRGLCI ERLSASPAQE KEAAPGKSEL CSSPLGKRPL NELMESEGKT VLSKMMGSPK SEFTKWTRIN EITSEPDRIT VSGHFHRLSR ELEKEKEDTQ GFTLGESPES EDDDSGDGMD VAGLDIETSF SSSSTLVALS VGSNPQSSSG LDCGNDTDIT TKVFSTEPHH SEHKLQTKTL NTLHLQSEPP ECSIGGNNLE NSLCALSPEL GASNFNDQKS SGIEYTKVVK GLTKIHSLPR SVFMKATKDG QCESQDPRIE LTLNKPDFTS LIGSQAALIK SGLGFVKSTS WHHSDLLRKG GEESLRAKSE HEQKTSHQLQ KAMPFLQNRG PTPKPDLLRE NNNPVEFKTT ASVLPNQVSV ITKQTRPEKV QSAKLEHLRP HRVEPTLVTE NSGNKTGMST VAKCDGERDD TTQNITEVAA VKSISPEVSA SRRKLDFNSP GGSSPVENSD CSTNSRLSFS PENILIQNQD IVREAAVQGD GQKQRQPQAT DLDSSGTHGS EMLPATEVTV SGGFSVEETS CGDTGRSGGE ALAVANDSTS TPQNANGLWK LKSTTPGGAL PECFGTTDTT FSSAFCRKHG ETQDTSQSSL PGTLHCYTGI REGGDDTEVE SEAFSCSEGS EQQDAPDDSQ KNLGDTDAAV AEVRPSLEVG YLTSALQDFN ISTFSELDRL STSEVVMFLE SCQLGDYSSG DSVSECSSKG TLSKEMNKEL KASEIGEKYR KQPCEEETLG TCEEWIESEE DDYSLKNTSQ LTQCSLETLS EVLTKIRQEL QTNSEDCNGK DTGSLLLLNV NNNMTTENLK EKSPFRETTG SSSHASEPTP QAAALDTEGS SPISGMPQNE NPQSRPEARS DAGRQTDGGE EDLPEPVEPS ALCSDSVMEP SIEQSSNCEA ETTFQCQIAT VTSEVINVLI NKDQNLVIEK GDNWTIISGV AVLPHVDQVT LCDIPGDIPI SQDQGELEAG CIPVTSAEKS PEASHTGPAF QEAPCGNNLS CPQEDVSSSG QSTNFDKSRL RNRPVKPSIW ISSQIYDQNF ETQIVASDHT YYNSKLEPSG KNKNRSKISN KDQSNKPVKT SASSRVETHQ SEVAQSFSGE KANTKTQRSQ TQTILANADT STPTDCSPDT LSKIRQEVGP PLPPLLAPLI ATPPRTSQPL SPLISSSSPS SPASPVGQVS PFRETPVPPA MSPWPEDPRR ASPPDPSPSP SAASASERVV PSPLQFCAAT PKHALPVPGR LPPCASGHAA VGGPQENSVK ILDTMYPELS ARARTLNILK GNIQLTRGPP ADCKNLPGPA SAMIGFKTIT SAATAFVKTG SSSGGDCNQD KSRDLGTQQD SSGKRTLSTS TLRSAKRLRL DTGSPEPETR GVTAEGIHKN LPGNLPPAEV ATTNEERSCS SPAVSAVSQL PLSPKETVES HDKAIANALK KIAEFSFDLL PVIRSHVYVG NISKKPVMRD QEKEVVYEFS TTKKHLAECL LHSILSELKI QKISMDHNYI HALCRVYVGI CRQLGDLERA RLFCYSLLKE DFPESEKLTL FIANMWHDIF LSQSVINKAM QLVARQRAKG EVLNCLRAFL NWEKNAPVDV GFMVSKLLLT IQLCPKTEFQ PSEKFGEDLS DNTWEYIFAI DLLCCHQKWI WTHDNIISKE LWPVMDKWIK YRKGHANIAY TPDIIIASIL RLIGRLGQLG LKEGFPSAVK NISSVIGMFI QHAHDEDIPW GIQLAAVYAL CDLSPSNPAE ISKILEAWRR EASKSVPSAI VSCLEEVSAL STEELG
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