About Trafficking protein particle complex subunit 8
Trafficking protein particle complex subunit 8 (TRAPPC8) is a protein
from Homo sapiens identified by UniProt accession
Q9Y2L5, 1435 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Trafficking protein particle complex subunit 8 |
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| UniProt accession | Q9Y2L5 |
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| Gene | TRAPPC8 |
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| Organism | Homo sapiens |
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| Length | 1435 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- TNF-related apoptosis-inducing ligand measurement · score 0.16
- type 1 diabetes mellitus · score 0.16
- vertebral disorder · score 0.11
- neutropenia, severe congenital, 1, autosomal dominant · score 0.03
- hereditary chronic pancreatitis · score 0.03
- drug use measurement · score 0.02
- human papilloma virus infection · score 0.02
- infection · score 0.01
- infect · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y2L5-F1 | alphafold | PREDICTED | 78.95 | — |
Amino-acid sequence (1435 residues)
MAQCVQSVQE LIPDSFVPCV AALCSDEAER LTRLNHLSFA ELLKPFSRLT SEVHMRDPNN QLHVIKNLKI AVSNIVTQPP QPGAIRKLLN DVVSGSQPAE GLVANVITAG DYDLNISATT PWFESYRETF LQSMPALDHE FLNHYLACML VASSSEAEPV EQFSKLSQEQ HRIQHNSDYS YPKWFIPNTL KYYVLLHDVS AGDEQRAESI YEEMKQKYGT QGCYLLKINS RTSNRASDEQ IPDPWSQYLQ KNSIQNQESY EDGPCTITSN KNSDNNLLSL DGLDNEVKDG LPNNFRAHPL QLEQSSDPSN SIDGPDHLRS ASSLHETKKG NTGIIHGACL TLTDHDRIRQ FIQEFTFRGL LPHIEKTIRQ LNDQLISRKG LSRSLFSATK KWFSGSKVPE KSINDLKNTS GLLYPPEAPE LQIRKMADLC FLVQHYDLAY SCYHTAKKDF LNDQAMLYAA GALEMAAVSA FLQPGAPRPY PAHYMDTAIQ TYRDICKNMV LAERCVLLSA ELLKSQSKYS EAAALLIRLT SEDSDLRSAL LLEQAAHCFI NMKSPMVRKY AFHMILAGHR FSKAGQKKHA LRCYCQAMQV YKGKGWSLAE DHINFTIGRQ SYTLRQLDNA VSAFRHILIN ESKQSAAQQG AFLREYLYVY KNVSQLSPDG PLPQLPLPYI NSSATRVFFG HDRRPADGEK QAATHVSLDQ EYDSESSQQW RELEEQVVSV VNKGVIPSNF HPTQYCLNSY SDNSRFPLAV VEEPITVEVA FRNPLKVLLL LTDLSLLWKF HPKDFSGKDN EEVKQLVTSE PEMIGAEVIS EFLINGEESK VARLKLFPHH IGELHILGVV YNLGTIQGSM TVDGIGALPG CHTGKYSLSM SVRGKQDLEI QGPRLNNTKE EKTSVKYGPD RRLDPIITEE MPLLEVFFIH FPTGLLCGEI RKAYVEFVNV SKCPLTGLKV VSKRPEFFTF GGNTAVLTPL SPSASENCSA YKTVVTDATS VCTALISSAS SVDFGIGTGS QPEVIPVPLP DTVLLPGASV QLPMWLRGPD EEGVHEINFL FYYESVKKQP KIRHRILRHT AIICTSRSLN VRATVCRSNS LENEEGRGGN MLVFVDVENT NTSEAGVKEF HIVQVSSSSK HWKLQKSVNL SENKDTKLAS REKGKFCFKA IRCEKEEAAT QSSEKYTFAD IIFGNEQIIS SASPCADFFY RSLSSELKKP QAHLPVHTEK QSTEDAVRLI QKCSEVDLNI VILWKAYVVE DSKQLILEGQ HHVILRTIGK EAFSYPQKQE PPEMELLKFF RPENITVSSR PSVEQLSSLI KTSLHYPESF NHPFHQKSLC LVPVTLLLSN CSKADVDVIV DLRHKTTSPE ALEIHGSFTW LGQTQYKLQL KSQEIHSLQL KACFVHTGVY NLGTPRVFAK LSDQVTVFET SQQNSMPALI IISNV
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