RNA 3'-terminal phosphate cyclase-like protein (RCL1)

About RNA 3'-terminal phosphate cyclase-like protein

RNA 3'-terminal phosphate cyclase-like protein (RCL1) is a protein from Homo sapiens identified by UniProt accession Q9Y2P8, 373 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	RNA 3'-terminal phosphate cyclase-like protein
UniProt accession	Q9Y2P8
Gene	RCL1
Organism	Homo sapiens
Length	373 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

platelet count · score 0.42
mean corpuscular volume · score 0.41
mean corpuscular hemoglobin · score 0.41
platelet crit · score 0.40
erythrocyte count · score 0.40
Red cell distribution width · score 0.39
mean corpuscular hemoglobin concentration · score 0.38
eosinophil count · score 0.36
red blood cell density measurement · score 0.35
reticulocyte count · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y2P8-F1	alphafold	PREDICTED	93.11	—

Amino-acid sequence (373 residues)

MATQAHSLSY AGCNFLRQRL VLSTLSGRPV KIRKIRARDD NPGLRDFEAS FIRLLDKITN GSRIEINQTG TTLYYQPGLL YGGSVEHDCS VLRGIGYYLE SLLCLAPFMK HPLKIVLRGV TNDQVDPSVD VLKATALPLL KQFGIDGESF ELKIVRRGMP PGGGGEVVFS CPVRKVLKPI QLTDPGKIKR IRGMAYSVRV SPQMANRIVD SARSILNKFI PDIYIYTDHM KGVNSGKSPG FGLSLVAETT SGTFLSAELA SNPQGQGAAV LPEDLGRNCA RLLLEEIYRG GCVDSTNQSL ALLLMTLGQQ DVSKVLLGPL SPYTIEFLRH LKSFFQIMFK IETKPCGEEL KGGDKVLMTC VGIGFSNLSK TLK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards