Y-box-binding protein 2 (YBX2)

About Y-box-binding protein 2

Y-box-binding protein 2 (YBX2) is a protein from Homo sapiens identified by UniProt accession Q9Y2T7, 364 residues long. MolForge cross-references it against 0 known binders and 197 disease associations.

Target properties

Protein name	Y-box-binding protein 2
UniProt accession	Q9Y2T7
Gene	YBX2
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (197)

Diseases linked to this target (Open Targets).

triglyceride measurement · score 0.22
body height · score 0.14
ST2 protein measurement · score 0.12
systolic blood pressure · score 0.09
mathematical ability · score 0.09
azoospermia · score 0.08
primary ovarian insufficiency · score 0.07
body fat percentage · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
partial chromosome Y deletion · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y2T7-F1	alphafold	PREDICTED	62.06	—

Amino-acid sequence (364 residues)

MSEVEAAAGA TAVPAATVPA TAAGVVAVVV PVPAGEPQKG GGAGGGGGAA SGPAAGTPSA PGSRTPGNPA TAVSGTPAPP ARSQADKPVL AIQVLGTVKW FNVRNGYGFI NRNDTKEDVF VHQTAIKRNN PRKFLRSVGD GETVEFDVVE GEKGAEATNV TGPGGVPVKG SRYAPNRRKS RRFIPRPPSV APPPMVAEIP SAGTGPGSKG ERAEDSGQRP RRWCPPPFFY RRRFVRGPRP PNQQQPIEGT DRVEPKETAP LEGHQQQGDE RVPPPRFRPR YRRPFRPRPR QQPTTEGGDG ETKPSQGPAD GSRPEPQRPR NRPYFQRRRQ QAPGPQQAPG PRQPAAPETS APVNSGDPTT TILE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards