About WW domain-binding protein 11
WW domain-binding protein 11 (WBP11) is a protein
from Homo sapiens identified by UniProt accession
Q9Y2W2, 641 residues long.
MolForge cross-references it against 0 known binders and
228 disease associations.
Target properties
| Protein name | WW domain-binding protein 11 |
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| UniProt accession | Q9Y2W2 |
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| Gene | WBP11 |
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| Organism | Homo sapiens |
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| Length | 641 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (228)
Diseases linked to this target (Open Targets).
- vertebral, cardiac, tracheoesophageal, renal, and limb defects · score 0.71
- genetic disorder · score 0.19
- BMI-adjusted hip circumference · score 0.18
- lean body mass · score 0.14
- body height · score 0.14
- appendicular lean mass · score 0.10
- fat body mass · score 0.08
- sitting height measurement · score 0.08
- base metabolic rate measurement · score 0.07
- autosomal recessive spondylocostal dysostosis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y2W2-F1 | alphafold | PREDICTED | 62.60 | — |
Amino-acid sequence (641 residues)
MGRRSTSSTK SGKFMNPTDQ ARKEARKREL KKNKKQRMMV RAAVLKMKDP KQIIRDMEKL DEMEFNPVQQ PQLNEKVLKD KRKKLRETFE RILRLYEKEN PDIYKELRKL EVEYEQKRAQ LSQYFDAVKN AQHVEVESIP LPDMPHAPSN ILIQDIPLPG AQPPSILKKT SAYGPPTRAV SILPLLGHGV PRLPPGRKPP GPPPGPPPPQ VVQMYGRKVG FALDLPPRRR DEDMLYSPEL AQRGHDDDVS STSEDDGYPE DMDQDKHDDS TDDSDTDKSD GESDGDEFVH RDNGERDNNE EKKSGLSVRF ADMPGKSRKK KKNMKELTPL QAMMLRMAGQ EIPEEGREVE EFSEDDDEDD SDDSEAEKQS QKQHKEESHS DGTSTASSQQ QAPPQSVPPS QIQAPPMPGP PPLGPPPAPP LRPPGPPTGL PPGPPPGAPP FLRPPGMPGL RGPLPRLLPP GPPPGRPPGP PPGPPPGLPP GPPPRGPPPR LPPPAPPGIP PPRPGMMRPP LVPPLGPAPP GLFPPAPLPN PGVLSAPPNL IQRPKADDTS AATIEKKATA TISAKPQITN PKAEITRFVP TALRVRRENK GATAAPQRKS EDDSAVPLAK AAPKSGPSVP VSVQTKDDVY EAFMKEMEGL L
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