Small kinetochore-associated protein (KNSTRN)

About Small kinetochore-associated protein

Small kinetochore-associated protein (KNSTRN) is a protein from Homo sapiens identified by UniProt accession Q9Y448, 316 residues long. MolForge cross-references it against 0 known binders and 278 disease associations.

Target properties

Protein name	Small kinetochore-associated protein
UniProt accession	Q9Y448
Gene	KNSTRN
Organism	Homo sapiens
Length	316 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (278)

Diseases linked to this target (Open Targets).

Combined immunodeficiency with facio-oculo-skeletal anomalies · score 0.50
combined immunodeficiency with faciooculoskeletal anomalies · score 0.45
neurodegenerative disease · score 0.35
cutaneous melanoma · score 0.31
skin squamous cell carcinoma · score 0.31
melanoma · score 0.21
hepatocellular carcinoma · score 0.21
lung adenocarcinoma · score 0.20
urinary bladder carcinoma · score 0.19
breast carcinoma · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y448-F1	alphafold	PREDICTED	67.50	—

Amino-acid sequence (316 residues)

MAAPEAPPLD RVFRTTWLST ECDSHPLPPS YRKFLFETQA ADLAGGTTVA AGNLLNESEK DCGQDRRAPG VQPCRLVTMT SVVKTVYSLQ PPSALSGGQP ADTQTRATSK SLLPVRSKEV DVSKQLHSGG PENDVTKITK LRRENGQMKA TDTATRRNVR KGYKPLSKQK SEEELKDKNQ LLEAVNKQLH QKLTETQGEL KDLTQKVELL EKFRDNCLAI LESKGLDPAL GSETLASRQE STTDHMDSML LLETLQEELK LFNETAKKQM EELQALKVKL EMKEERVRFL EQQTLCNNQV NDLTTALKEM EQLLEM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards