Transducin beta-like protein 2 (TBL2)

About Transducin beta-like protein 2

Transducin beta-like protein 2 (TBL2) is a protein from Homo sapiens identified by UniProt accession Q9Y4P3, 447 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.

Target properties

Protein name	Transducin beta-like protein 2
UniProt accession	Q9Y4P3
Gene	TBL2
Organism	Homo sapiens
Length	447 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (134)

Diseases linked to this target (Open Targets).

triglyceride measurement · score 0.36
blood protein measurement · score 0.27
mean corpuscular volume · score 0.27
physical activity · score 0.23
diacylglycerol 34:3 measurement · score 0.23
alkaline phosphatase measurement · score 0.22
gout · score 0.21
sphingomyelin measurement · score 0.21
serum alanine aminotransferase measurement · score 0.20
cystatin C measurement · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y4P3-F1	alphafold	PREDICTED	87.10	—

Amino-acid sequence (447 residues)

MELSQMSELM GLSVLLGLLA LMATAAVARG WLRAGEERSG RPACQKANGF PPDKSSGSKK QKQYQRIRKE KPQQHNFTHR LLAAALKSHS GNISCMDFSS NGKYLATCAD DRTIRIWSTK DFLQREHRSM RANVELDHAT LVRFSPDCRA FIVWLANGDT LRVFKMTKRE DGGYTFTATP EDFPKKHKAP VIDIGIANTG KFIMTASSDT TVLIWSLKGQ VLSTINTNQM NNTHAAVSPC GRFVASCGFT PDVKVWEVCF GKKGEFQEVV RAFELKGHSA AVHSFAFSND SRRMASVSKD GTWKLWDTDV EYKKKQDPYL LKTGRFEEAA GAAPCRLALS PNAQVLALAS GSSIHLYNTR RGEKEECFER VHGECIANLS FDITGRFLAS CGDRAVRLFH NTPGHRAMVE EMQGHLKRAS NESTRQRLQQ QLTQAQETLK SLGALKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards