About Neurogenin-3
Neurogenin-3 (NEUROG3) is a protein
from Homo sapiens identified by UniProt accession
Q9Y4Z2, 214 residues long.
MolForge cross-references it against 0 known binders and
114 disease associations.
Target properties
| Protein name | Neurogenin-3 |
|---|
| UniProt accession | Q9Y4Z2 |
|---|
| Gene | NEUROG3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 214 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (114)
Diseases linked to this target (Open Targets).
- congenital malabsorptive diarrhea 4 · score 0.70
- Congenital malabsorptive diarrhea due to paucity of enteroendocrine cells · score 0.66
- neurodegenerative disease · score 0.53
- type 2 diabetes mellitus · score 0.48
- diabetes mellitus · score 0.43
- permanent neonatal diabetes mellitus · score 0.38
- body height · score 0.36
- drug use measurement · score 0.31
- IGF-1 measurement · score 0.26
- head and neck squamous cell carcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y4Z2-F1 | alphafold | PREDICTED | 68.99 | — |
Amino-acid sequence (214 residues)
MTPQPSGAPT VQVTRETERS FPRASEDEVT CPTSAPPSPT RTRGNCAEAE EGGCRGAPRK LRARRGGRSR PKSELALSKQ RRSRRKKAND RERNRMHNLN SALDALRGVL PTFPDDAKLT KIETLRFAHN YIWALTQTLR IADHSLYALE PPAPHCGELG SPGGSPGDWG SLYSPVSQAG SLSPAASLEE RPGLLGATFS ACLSPGSLAF SDFL
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