Mitochondrial import inner membrane translocase…

About Mitochondrial import inner membrane translocase subunit Tim22

Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) is a protein from Homo sapiens identified by UniProt accession Q9Y584, 194 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	Mitochondrial import inner membrane translocase subunit Tim22
UniProt accession	Q9Y584
Gene	TIMM22
Organism	Homo sapiens
Length	194 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

combined oxidative phosphorylation deficiency 43 · score 0.46
bone quantitative ultrasound measurement · score 0.16
heel bone mineral density · score 0.15
bone density · score 0.12
body height · score 0.12
cortical surface area measurement · score 0.11
blood phosphate measurement · score 0.11
appendicular lean mass · score 0.11
brain measurement · score 0.08
attention deficit hyperactivity disorder · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y584-F1	alphafold	PREDICTED	79.44	—

Amino-acid sequence (194 residues)

MAAAAPNAGG SAPETAGSAE APLQYSLLLQ YLVGDKRQPR LLEPGSLGGI PSPAKSEEQK MIEKAMESCA FKAALACVGG FVLGGAFGVF TAGIDTNVGF DPKDPYRTPT AKEVLKDMGQ RGMSYAKNFA IVGAMFSCTE CLIESYRGTS DWKNSVISGC ITGGAIGFRA GLKAGAIGCG GFAAFSAAID YYLR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22)