About Kallikrein-4
Kallikrein-4 (KLK4) is a protein
from Homo sapiens identified by UniProt accession
Q9Y5K2, 254 residues long.
MolForge cross-references it against 0 known binders and
575 disease associations.
Target properties
| Protein name | Kallikrein-4 |
|---|
| UniProt accession | Q9Y5K2 |
|---|
| Gene | KLK4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 254 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (575)
Diseases linked to this target (Open Targets).
- Hypomaturation amelogenesis imperfecta · score 0.66
- amelogenesis imperfecta · score 0.51
- genetic disorder · score 0.19
- male infertility · score 0.11
- neoplasm · score 0.10
- COVID-19 · score 0.08
- acute kidney failure · score 0.07
- dental caries · score 0.07
- Hypoplastic amelogenesis imperfecta · score 0.07
- cancer · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y5K2-F1 | alphafold | PREDICTED | 90.10 | — |
Amino-acid sequence (254 residues)
MATAGNPWGW FLGYLILGVA GSLVSGSCSQ IINGEDCSPH SQPWQAALVM ENELFCSGVL VHPQWVLSAA HCFQNSYTIG LGLHSLEADQ EPGSQMVEAS LSVRHPEYNR PLLANDLMLI KLDESVSESD TIRSISIASQ CPTAGNSCLV SGWGLLANGR MPTVLQCVNV SVVSEEVCSK LYDPLYHPSM FCAGGGHDQK DSCNGDSGGP LICNGYLQGL VSFGKAPCGQ VGVPGVYTNL CKFTEWIEKT VQAS
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