Retinoic acid-induced protein 2 (RAI2)

About Retinoic acid-induced protein 2

Retinoic acid-induced protein 2 (RAI2) is a protein from Homo sapiens identified by UniProt accession Q9Y5P3, 530 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

Target properties

Protein name	Retinoic acid-induced protein 2
UniProt accession	Q9Y5P3
Gene	RAI2
Organism	Homo sapiens
Length	530 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

prurigo · score 0.25
Dextrocardia · score 0.11
neoplasm · score 0.06
Gollop-Wolfgang complex · score 0.05
hepatocellular carcinoma · score 0.05
gonorrhea · score 0.05
tibia, hypoplasia or aplasia of, with polydactyly · score 0.05
Blount disease · score 0.05
breast cancer · score 0.05
acheiropody · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y5P3-F1	alphafold	PREDICTED	50.02	—

Amino-acid sequence (530 residues)

MDDLQSQNLS MDMTDSPPAL ANNRLENGMA QLITTEAWNI NSTDLVKKAL VTVPAPSILN PPAESQSGMA LKVAATVLQP LCLGESPVVM PIHMQVEGSS APELNPNGNA TYVMTTQGPV QLPVVLEQHV FQHLNSPLVL PQEAPCSSST IHNNLFQGAE DPEAQPQLLD LRIPSQPQEP TLPFEAVLQN LFPSQGTLGP PPCQPPPGYA PVPPQPFSSP LSPLVPPATL LVPYPVIVPL PVPVPIPIPI PMPQSSESKF SSSFPKPPSS FGLHPFKGTQ TPLEKDELKP FDILQPKEYF QLSRHTVIKM GSENEALDLS MKSVPWLKAG EVSPPIFQED AALDLSVAAH RKSEPPPETL YDSGASVDSS GHTVMEKLPS GMEISFAPAT SHEAPAMMDS HISSSDAATE MLSQPNHPSG EVKAENNIEM VGESQAAKVI VSVEDAVPTI FCGKIKGLSG VSTKNFSFKR EDSVLQGYDI NSQGEESMGN AEPLRKPIKN RSIKLKKVNS QEIHMLPIKK QRLATFFPRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards