About Calcium-activated potassium channel subunit beta-2
Calcium-activated potassium channel subunit beta-2 (KCNMB2) is a protein
from Homo sapiens identified by UniProt accession
Q9Y691, 235 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | Calcium-activated potassium channel subunit beta-2 |
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| UniProt accession | Q9Y691 |
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| Gene | KCNMB2 |
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| Organism | Homo sapiens |
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| Length | 235 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (23)
Diseases linked to this target (Open Targets).
- Self-injurious behavior · score 0.26
- neurodegenerative disease · score 0.25
- adolescent idiopathic scoliosis · score 0.24
- insomnia measurement · score 0.18
- calcium measurement · score 0.17
- drug use measurement · score 0.15
- protein measurement · score 0.15
- metabolite measurement · score 0.06
- acute myeloid leukemia · score 0.01
- clear cell renal carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y691-F1 | alphafold | PREDICTED | 85.50 | — |
Amino-acid sequence (235 residues)
MFIWTSGRTS SSYRHDEKRN IYQKIRDHDL LDKRKTVTAL KAGEDRAILL GLAMMVCSIM MYFLLGITLL RSYMQSVWTE ESQCTLLNAS ITETFNCSFS CGPDCWKLSQ YPCLQVYVNL TSSGEKLLLY HTEETIKINQ KCSYIPKCGK NFEESMSLVN VVMENFRKYQ HFSCYSDPEG NQKSVILTKL YSSNVLFHSL FWPTCMMAGG VAIVAMVKLT QYLSLLCERI QRINR
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