Acoltremon

TRPM8 Thermoreceptor Agonist

Key facts

Acoltremon is an onp drug in the TRPM8 Thermoreceptor Agonist class catalogued in DrugCentral. It was first approved by the FDA in 2025. Its mechanism of action is classified as TRPM8 Thermoreceptor Agonists. DrugCentral lists 2 molecular targets, including TRPM8 and Trpm8. Recorded indications include Dry eye disease.

• Approval status: onp (first approved 2025 by the FDA).
• Drug class: TRPM8 Thermoreceptor Agonist.
• Mechanism of action: TRPM8 Thermoreceptor Agonists.
• Molecular targets: TRPM8 and Trpm8 (2 listed in DrugCentral).
• Indications: Dry eye disease.
• Molecular formula: C18H27NO2; molecular weight 289.42 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Dry eye disease

Mechanism & targets

• Mechanism of action (MoA): TRPM8 Thermoreceptor Agonists
• Established pharmacologic class: TRPM8 Thermoreceptor Agonist

Molecular targets (2)

Target	Gene	Action	Activity
Transient receptor potential cation channel subfamily M member 8	TRPM8	agonist	EC50 6.00
Transient receptor potential cation channel subfamily M member 8	Trpm8	activator	EC50 4.90

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2025-05-28	FDA	—	ALCON LABS INC

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Eye irritation	6613.6
Eye pain	1562.8
Ocular hyperaemia	712.4
Drug ineffective	434.4
Vision blurred	402.4
Lacrimation increased	319.3
Ocular discomfort	312.4
Eye pruritus	228.2

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Acoltremon is on its molecule page.

• Molecular formula: C₁₈H₂₇NO₂
• Molecular weight: 289.42 g/mol
• CAS number: —
• InChIKey: HNSGVPAAXJJOPQ-XOKHGSTOSA-N
• PubChem CID: 11266244

C[C@@H]1CC[C@H]([C@@H](C1)C(=O)NC2=CC=C(C=C2)OC)C(C)C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Acoltremon used for?

DrugCentral lists the following indications for Acoltremon: Dry eye disease.

How does Acoltremon work?

Acoltremon is classified as TRPM8 Thermoreceptor Agonists; its molecular targets in DrugCentral include TRPM8 (agonist) and Trpm8 (activator).

When was Acoltremon first approved?

Acoltremon was first approved by the FDA in 2025.

What drug class does Acoltremon belong to?

Acoltremon is in the TRPM8 Thermoreceptor Agonist class.

What is the chemical formula of Acoltremon?

Acoltremon has the molecular formula C18H27NO2 and a molecular weight of 289.42 g/mol.

Sources

• DrugCentral drug card 5773 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2441929 — compound record and bioactivity
• PubChem CID 11266244 — chemical identifiers
• FDA UNII 1L7BVT4Z4Z — substance identity
• DailyMed: FDA labels for Acoltremon — current prescribing information (label search)
• UniProt Q7Z2W7 (TRPM8) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.