Adenine

Drug profile

Key facts

Adenine is a drug catalogued in DrugCentral. It was first approved by the FDA in 2021. DrugCentral lists 3 molecular targets, including LRRK2, XDH and PI4KA|PI4K2B|PI4K2A|PI4KB.

• Molecular targets: LRRK2, XDH and PI4KA|PI4K2B|PI4K2A|PI4KB (3 listed in DrugCentral).
• Molecular formula: C5H5N5; molecular weight 135.13 g/mol.

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Leucine-rich repeat serine/threonine-protein kinase 2	LRRK2	unknown	Ki 5.17
Xanthine dehydrogenase/oxidase	XDH	unknown	IC50 4.96
Phosphatidylinositol 4-kinase, PI4K	PI4KA|PI4K2B|PI4K2A|PI4KB	unknown	Ki 4.07

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2021-04-08	FDA	—	—

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Adenine is on its molecule page.

• Molecular formula: C₅H₅N₅
• Molecular weight: 135.13 g/mol
• CAS number: 73-24-5
• InChIKey: GFFGJBXGBJISGV-UHFFFAOYSA-N
• PubChem CID: 190

NC1=NC=NC2=C1NC=N2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Adenine work?

Its molecular targets in DrugCentral include LRRK2, XDH and PI4KA|PI4K2B|PI4K2A|PI4KB.

When was Adenine first approved?

Adenine was first approved by the FDA in 2021.

What is the chemical formula of Adenine?

Adenine has the molecular formula C5H5N5 and a molecular weight of 135.13 g/mol.

Sources

• DrugCentral drug card 89 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1797130 — compound record and bioactivity
• PubChem CID 190 — chemical identifiers
• DrugBank DB00173 — drug record
• FDA UNII JAC85A2161 — substance identity
• DailyMed: FDA labels for Adenine — current prescribing information (label search)
• UniProt Q5S007 (LRRK2) — target protein
• UniProt P47989 (XDH) — target protein

How this page is built: methodology · editorial policy & corrections.